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HOWARD BERNSTEIN, NATHAN ZVAIFLER, MARTIN RUBIN, AGNES MARY MANSOUR; The Ocular Deposition of Chloroquine. Invest. Ophthalmol. Vis. Sci. 1963;2(4):384-392.
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Chloroquine is stored in the iris and choroid of the pigmented rabbit and rat in concentrations significantly greater than in other tissues of the body. The drug cannot be detected in the uveal tissues of comparable albino animals. Following a single intravenous dose of 5 mg. per kilogram of chloroquine dihydrochloride, the drug is retained in the uveal tract of the pigmented rabbit eye in high concentration for at least 1 month. In pigmented rats receiving daily oral chloroquine phosphate for 6 months, the iris contained 80 times as much drug as the liver. This storage of chloroquine in the pigmented uvea may represent a binding of the drug to melanin pigment, similar to that recently described for the phenothiazine derivatives. The correlation of these findings with the clinical and histologic appearance of chloroquine retinopathy is discussed.
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