February 1989
Volume 30, Issue 2
Free
Articles  |   February 1989
Retinal pigment epithelium possesses both LDL and scavenger receptor activity.
Author Affiliations
  • K C Hayes
    Foster Biomedical Research Laboratory, Brandeis University, Waltham, Massachusetts 02254.
  • S Lindsey
    Foster Biomedical Research Laboratory, Brandeis University, Waltham, Massachusetts 02254.
  • Z F Stephan
    Foster Biomedical Research Laboratory, Brandeis University, Waltham, Massachusetts 02254.
  • D Brecker
    Foster Biomedical Research Laboratory, Brandeis University, Waltham, Massachusetts 02254.
Investigative Ophthalmology & Visual Science February 1989, Vol.30, 225-232. doi:
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      K C Hayes, S Lindsey, Z F Stephan, D Brecker; Retinal pigment epithelium possesses both LDL and scavenger receptor activity.. Invest. Ophthalmol. Vis. Sci. 1989;30(2):225-232.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The lipid metabolism of photoreceptors depends in part on the retinal pigment epithelium (RPE). One aspect of cholesterol homeostasis in cultured bovine RPE was evaluated by measuring low-density lipoprotein (LDL) and scavenger receptor activity with [125I]-LDL and [125I]Ac-LDL, respectively. Incubation of RPE cells in the presence of increasing concentrations of LDL or Ac-LDL resulted in down-regulation of the LDL receptor but not the scavenger receptor, patterns consistent with the presence of both receptors on these cells. This receptor profile distinguishes the RPE cell from fibroblasts and indicates its similarity to macrophages and arterial endothelial cells.

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