March 1988
Volume 29, Issue 3
Free
Articles  |   March 1988
Donor age influences on the success of retinal grafts to adult rat retina.
Author Affiliations
  • R Aramant
    Department of Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.
  • M Seiler
    Department of Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.
  • J E Turner
    Department of Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.
Investigative Ophthalmology & Visual Science March 1988, Vol.29, 498-503. doi:
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      R Aramant, M Seiler, J E Turner; Donor age influences on the success of retinal grafts to adult rat retina.. Invest. Ophthalmol. Vis. Sci. 1988;29(3):498-503.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The rat retina can be successfully grafted within a long time period which extends into the first 2 weeks of postnatal life. Postnatal grafts taken 1-2 days (PN 1-2) after birth demonstrate no significant differences in their ability to form successful grafts. However, grafting success begins to diminish gradually starting between PN 2-4 and reaches a low point in organization and survival by PN 14. PN 21 grafts rapidly degenerate by 1 to 2 days after transplantation. Although early postnatal retinal tissue can be successfully grafted, E 15 embryonic retinas make better grafts for their ability to form consistent laminae and to integrate with host tissue in a fresh lesion paradigm.

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