June 1986
Volume 27, Issue 6
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Articles  |   June 1986
Transport of fluorescein monoglucuronide out of the vitreous.
Investigative Ophthalmology & Visual Science June 1986, Vol.27, 998-1001. doi:
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      S Kitano, S Nagataki; Transport of fluorescein monoglucuronide out of the vitreous.. Invest. Ophthalmol. Vis. Sci. 1986;27(6):998-1001.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The transport of fluorescein monoglucuronide, a fluorescent metabolite of fluorescein, from the vitreous was studied. Ten microliter of 1 mM fluorescein monoglucuronide or fluorescein solution was injected into the rabbit vitreous body, and the vitreous concentration was measured every 2 hr. The rate of loss from the vitreous was 0.066 +/- 0.012 (SD)/hour for fluorescein monoglucuronide and 0.22 +/- 0.029/hour for fluorescein. Systemically administered probenecid caused a statistically significant reduction in the loss from the vitreous of each of them.

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