May 1986
Volume 27, Issue 5
Free
Articles  |   May 1986
Immunocytochemical localization of fibronectin to the retinal pigment epithelium of the rat.
Investigative Ophthalmology & Visual Science May 1986, Vol.27, 840-844. doi:
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      R M Pino; Immunocytochemical localization of fibronectin to the retinal pigment epithelium of the rat.. Invest. Ophthalmol. Vis. Sci. 1986;27(5):840-844.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Fibronectin is an anionic asialoglycoprotein that is found on a variety of cell types. This study was undertaken in an attempt to localize fibronectin to the rat retinal pigment epithelium with ultrastructural immunocytochemistry. Using Fab-HRP conjugates specific for fibronectin, reaction product was localized on the surface of the apical processes and within the cell to GERL. After treatment of tissue by the biotin-avidin method employing ferritin-avidin, ferritin particles marked the apical processes in a quasi-regular distribution. Tufts of particles were separated by a linear distance of 65-85 nm. Fibronectin was not localized to rod outer segments.

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