February 1987
Volume 28, Issue 2
Free
Articles  |   February 1987
Cholinergic drugs alter ciliary muscle response and receptor content.
Author Affiliations
  • K A Erickson-Lamy
    Department of Ophthalmology, Medical Schools, of the University of Wisconsin, Madison, USA.
  • J R Polansky
    Department of Ophthalmology, Medical Schools, of the University of Wisconsin, Madison, USA.
  • P L Kaufman
    Department of Ophthalmology, Medical Schools, of the University of Wisconsin, Madison, USA.
  • D M Zlock
    Department of Ophthalmology, Medical Schools, of the University of Wisconsin, Madison, USA.
Investigative Ophthalmology & Visual Science February 1987, Vol.28, 375-383. doi:
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      K A Erickson-Lamy, J R Polansky, P L Kaufman, D M Zlock; Cholinergic drugs alter ciliary muscle response and receptor content.. Invest. Ophthalmol. Vis. Sci. 1987;28(2):375-383.

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Abstract

Topical echothiophate administration to the cynomolgus monkey eye for 5-6.5 months produced marked subsensitivity of the accommodative response to pilocarpine and a 65% decrease in specific high affinity 3H-QNB binding sites (ostensibly indicating muscarinic receptors) in the ciliary muscle. The decrease in 3H-QNB binding sites was quantitatively similar in surgically untouched, totally iridectomized, and ciliary muscle disinserted eyes. Following a 5-month off treatment recovery period, 3H-QNB binding sites increased to more than twice the number in untreated control eyes. In echothiophate-treated eyes whose contralateral eyes had previously received atropine+echothiophate, 3H-QNB binding sites were three to six times more numerous than in other long-term echothiophate-treated eyes, and one to two times more numerous than in untreated controls. Topical pilocarpine administration for 1 day to 7 months reduced ciliary muscle 3H-QNB binding sites by approximately 25%. Alterations in muscarinic receptors during and following cholinergic drug therapy may in part explain the observed subsensitization and recovery of ciliary muscle physiological responses.

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