December 1989
Volume 30, Issue 12
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Articles  |   December 1989
Adenosine: autoradiographic localization and electrophysiologic effects in the cat retina.
Author Affiliations
  • C Blazynski
    Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri.
  • A I Cohen
    Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri.
  • B Früh
    Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri.
  • G Niemeyer
    Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri.
Investigative Ophthalmology & Visual Science December 1989, Vol.30, 2533-2536. doi:
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    • Get Citation

      C Blazynski, A I Cohen, B Früh, G Niemeyer; Adenosine: autoradiographic localization and electrophysiologic effects in the cat retina.. Invest. Ophthalmol. Vis. Sci. 1989;30(12):2533-2536.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Autoradiography with 3H-adenosine was used to localize cells that accumulate adenosine in the cat retina. Electrophysiologic effects elicited by adenosine on DC-electroretinograms (ERG) and optic nerve responses (ONR) were studied in isolated, arterially perfused cat eyes. Subpopulations of cells localized in the ganglion cell layer and inner nuclear layer showed clear labeling for adenosine. This purine nucleoside enhanced the ERG b-wave and the standing potential; depressed the light peak; and markedly depressed the ONR, in which it reduced the amplitudes of the ON-, plateau-, and OFF-components. A vasodilatory action of adenosine was documented by an increase in perfusion flow rate. Our data suggest that adenosine in cat retina has complex modulatory effects, involving the retinal pigment epithelium, neuronal structures, blood vessels, and probably glial cells.

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