August 1990
Volume 31, Issue 8
Free
Articles  |   August 1990
Analysis of genes coding for S-antigen, interstitial retinol binding protein, and the alpha-subunit of cone transducin in patients with retinitis pigmentosa.
Author Affiliations
  • P J Ringens
    Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Boston, Massachusetts.
  • M Fang
    Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Boston, Massachusetts.
  • T Shinohara
    Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Boston, Massachusetts.
  • C D Bridges
    Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Boston, Massachusetts.
  • C L Lerea
    Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Boston, Massachusetts.
  • E L Berson
    Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Boston, Massachusetts.
  • T P Dryja
    Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Boston, Massachusetts.
Investigative Ophthalmology & Visual Science August 1990, Vol.31, 1421-1426. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      P J Ringens, M Fang, T Shinohara, C D Bridges, C L Lerea, E L Berson, T P Dryja; Analysis of genes coding for S-antigen, interstitial retinol binding protein, and the alpha-subunit of cone transducin in patients with retinitis pigmentosa.. Invest. Ophthalmol. Vis. Sci. 1990;31(8):1421-1426.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
This content is PDF only. Please click on the PDF icon to access.
Abstract

We screened 526 unrelated patients with autosomal dominant, autosomal recessive, or simplex retinitis pigmentosa for evidence of mutations of the genes encoding S-antigen (S-Ag), interstitial retinol binding protein (IRBP), and the alpha-subunit of cone-specific transducin. Restriction fragment length polymorphisms (RFLPs) were identified at each of these loci. Within each set of patients with a particular genetic type of retinitis pigmentosa, RFLP alleles at each of these loci showed no departure from Hardy-Weinberg equilibrium. No gene deletions or rearrangements could be detected in any patient. Furthermore, in each of six pedigrees (one autosomal dominant, one autosomal recessive, three Usher's syndrome type I, and one Laurence-Moon-Bardet-Biedl syndrome) there was no co-segregation of the disease with alleles determined by RFLPs at the locus for S-antigen. At the IRBP locus, lack of co-segregation was seen in one autosomal dominant, two autosomal recessive, and three Usher's syndrome type I pedigrees. Finally, one pedigree with autosomal recessive retinitis pigmentosa showed no co-segregation of the disease with alleles at the locus for the alpha-subunit of the cone-specific transducin. These data support the idea that the genes coding for S-Ag, IRBP, and the alpha-subunit of the cone-specific transducin do not play an etiologic role in the families with retinitis pigmentosa so far studied.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×