December 1991
Volume 32, Issue 13
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Articles  |   December 1991
Cellular retinoic acid-binding protein in rat lacrimal gland.
K Yamaguchi; V P Gaur; R W Young; A J Sweatt
Author Affiliations
  • K Yamaguchi
    Department of Ophthalmology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157.
  • V P Gaur
    Department of Ophthalmology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157.
  • R W Young
    Department of Ophthalmology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157.
  • A J Sweatt
    Department of Ophthalmology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157.
Investigative Ophthalmology & Visual Science December 1991, Vol.32, 3273-3276. doi:
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      K Yamaguchi, V P Gaur, R W Young, A J Sweatt; Cellular retinoic acid-binding protein in rat lacrimal gland.. Invest. Ophthalmol. Vis. Sci. 1991;32(13):3273-3276.

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Abstract

We employed a monoclonal antibody to cellular retinoic acid-binding protein (CRABP) to assess the presence and localization of this retinoid-binding protein in the lacrimal gland of the rat. Immunoblots of extracts of rat lacrimal gland showed specific immunostaining of lacrimal CRABP in the region 14-16 kDa. Sections of rat lacrimal glands that were stained with anti-CRABP antibodies showed reaction product in the cytoplasm of the acinar cells. Retinoic acid may play a role in maintaining the proper function of lacrimal gland cells.

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