January 1992
Volume 33, Issue 1
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Articles  |   January 1992
Ouabain-sensitive Na-K ATPase response in the rabbit iris-ciliary body after lensectomy-vitrectomy.
Author Affiliations
  • T Mito
    Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan.
  • S Ishiguro
    Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan.
  • M Tamai
    Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan.
Investigative Ophthalmology & Visual Science January 1992, Vol.33, 172-177. doi:
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      T Mito, S Ishiguro, M Tamai; Ouabain-sensitive Na-K ATPase response in the rabbit iris-ciliary body after lensectomy-vitrectomy.. Invest. Ophthalmol. Vis. Sci. 1992;33(1):172-177.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

We studied ouabain-sensitive Na-K adenosine triphosphatase (ATPase) activities in the iris-ciliary body of rabbit eyes after lensectomy-vitrectomy. Changes in enzyme activities were quantitatively investigated in the plasma membrane of iris-ciliary body at 0 or 7 hours and at days 1, 3, 7, and 14. The specific activity of Na-K ATPase rose to significantly higher levels than the control value at 7 hours following surgery, but returned to the baseline value after 7 days. In addition, we evaluated enzyme activities after lensectomy-vitrectomy during which SF6 or silicone oil was injected. The specific activity of Na-K ATPase following the injection of SF6 or silicone oil was significantly higher than the control value at 7 hours and did not return to the normal value even after 14 days. Consensual reaction, demonstrated by increased Na-K ATPase activity, also was found in the contralateral unoperated eyes of SF6- and silicone oil-injected rabbits. The increased Na-K ATPase activity in the iris-ciliary body after experimental surgery may play an important role in restoring swollen tissues.

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