September 1992
Volume 33, Issue 10
Free
Articles  |   September 1992
Transcriptional activity of HIV-1 and HHV-6 in retinal lesions from AIDS patients.
Author Affiliations
  • H B Qavi
    Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030.
  • M T Green
    Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030.
  • G K SeGall
    Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030.
  • D E Lewis
    Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030.
  • F B Hollinger
    Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030.
Investigative Ophthalmology & Visual Science September 1992, Vol.33, 2759-2767. doi:
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    • Get Citation

      H B Qavi, M T Green, G K SeGall, D E Lewis, F B Hollinger; Transcriptional activity of HIV-1 and HHV-6 in retinal lesions from AIDS patients.. Invest. Ophthalmol. Vis. Sci. 1992;33(10):2759-2767.

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Abstract

This study determined the frequency of multiple viral (HIV-1, HHV-6, and CMV) infections in 26 retinas from 16 AIDS patients. Of the 12 retinas of 26 that tested positive for HIV-1 DNA sequences, seven also were positive for HHV-6 DNA sequences. Four of these seven retinas were culture positive for HIV-1 and two of the four contained CMV DNA sequences and antigens. Using RNA probes, HIV-1 and HHV-6 transcriptional activity was demonstrated in two of the four HIV-1 culture positive retinas. These retinas also contained CMV DNA sequences and antigens. The results demonstrate that more than 35% of AIDS patients suffer from at least two simultaneous viral infections and 15% suffer from three viral infections. The presence of transcriptional activity of HIV-1 and HHV-6 suggests an active infection.

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