September 1989
Volume 30, Issue 9
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Articles  |   September 1989
Vitreous modulation of migration and proliferation of retinal pigment epithelial cells in vitro.
Author Affiliations
  • B Kirchhof
    Department of Ophthalmology, University of Southern California School of Medicine, Los Angeles.
  • E Kirchhof
    Department of Ophthalmology, University of Southern California School of Medicine, Los Angeles.
  • S J Ryan
    Department of Ophthalmology, University of Southern California School of Medicine, Los Angeles.
  • N Sorgente
    Department of Ophthalmology, University of Southern California School of Medicine, Los Angeles.
Investigative Ophthalmology & Visual Science September 1989, Vol.30, 1951-1957. doi:
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    • Get Citation

      B Kirchhof, E Kirchhof, S J Ryan, N Sorgente; Vitreous modulation of migration and proliferation of retinal pigment epithelial cells in vitro.. Invest. Ophthalmol. Vis. Sci. 1989;30(9):1951-1957.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Retinal pigment epithelial (RPE) cell migration and proliferation are believed to play a role in the pathogenesis of proliferative vitreoretinopathy (PVR). Since PVR develops in situations where vitreous contacts the RPE, we sought to determine whether human vitreous contains factors that stimulate proliferation and migration of RPE cells. We found that postmortem human vitreous stimulates migration but not proliferation of human RPE cells under serum-free conditions in vitro. Stimulation of proliferation of RPE cells and fibroblasts was observed, however, following admixture of albumin with the vitreous. These findings suggest that vitreous contributes modulators that stimulate some functions of RPE cells that are believed to play a role in the pathogenesis of PVR.

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