August 1991
Volume 32, Issue 9
Articles  |   August 1991
VEP projections in congenital nystagmus; VEP asymmetry in albinism: a comparison study.
Author Affiliations
  • P Apkarian
    Netherlands Ophthalmic Research Institute, Amsterdam.
  • J Shallo-Hoffmann
    Netherlands Ophthalmic Research Institute, Amsterdam.
Investigative Ophthalmology & Visual Science August 1991, Vol.32, 2653-2661. doi:
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      P Apkarian, J Shallo-Hoffmann; VEP projections in congenital nystagmus; VEP asymmetry in albinism: a comparison study.. Invest. Ophthalmol. Vis. Sci. 1991;32(9):2653-2661.

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      © ARVO (1962-2015); The Authors (2016-present)

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Visual evoked potential (VEP) asymmetry in which a preponderance of nasal and temporal retina afferents project to the contralateral hemisphere after full-field monocular stimulation is considered specific to albinism. Some reports, however, suggest that patients with congenital nystagmus (CN) share the albino-like visual pathway anomaly. To examine the clinical specificity of albino misrouting, VEP topography was assessed in ten patients with congenital nystagmus and in ten age-matched albino patients. As an additional control, the VEP response profiles from eight albino patients with no nystagmus were also evaluated. The results are definitive; VEP contralateral asymmetry reflecting temporal retinal misprojection is evinced only in albino patients. Furthermore, ocular-motor instabilities in CN cannot be readily attributed to albino-type misrouted retinal-cortical projections.


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