September 1992
Volume 33, Issue 10
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Articles  |   September 1992
The cancer-associated retinopathy antigen is a recoverin-like protein.
Author Affiliations
  • C E Thirkill
    Ophthalmology Research, University of California Davis Medical Center, Sacramento.
  • R C Tait
    Ophthalmology Research, University of California Davis Medical Center, Sacramento.
  • N K Tyler
    Ophthalmology Research, University of California Davis Medical Center, Sacramento.
  • A M Roth
    Ophthalmology Research, University of California Davis Medical Center, Sacramento.
  • J L Keltner
    Ophthalmology Research, University of California Davis Medical Center, Sacramento.
Investigative Ophthalmology & Visual Science September 1992, Vol.33, 2768-2772. doi:
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    • Get Citation

      C E Thirkill, R C Tait, N K Tyler, A M Roth, J L Keltner; The cancer-associated retinopathy antigen is a recoverin-like protein.. Invest. Ophthalmol. Vis. Sci. 1992;33(10):2768-2772.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Cancer-associated retinopathy (CAR) is a rare form of retinal degeneration that occurs in association with certain forms of cancer. CAR patients typically possess high titers of autoantibodies against a specific photoreceptor protein--the 23 kD retinal CAR antigen. The mechanisms involved in the vision loss experienced by CAR patients are not understood, but serologic studies indicate the process could include a series of autoimmune reactions directed at specific components of the retina. Because the retinal CAR antigen is the principal ocular autoantigen involved in the antibody response of CAR patients, characterizing it would contribute to the understanding of putative autoimmune involvement. Serum antibodies from CAR patients have been used to isolate the gene encoding the CAR antigen from a cDNA library of human retina. Nucleotide sequence analysis suggests that the CAR antigen shows approximately 90% homology to the published amino acid sequence of bovine recoverin.

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