April 1989
Volume 30, Issue 4
Free
Articles  |   April 1989
Temporal sequence of changes to the gray squirrel retina after near-UV exposure.
Author Affiliations
  • R J Collier
    Department of Ophthalmology, University of Rochester, School of Medicine and Dentistry, NY 14642.
  • W R Waldron
    Department of Ophthalmology, University of Rochester, School of Medicine and Dentistry, NY 14642.
  • S Zigman
    Department of Ophthalmology, University of Rochester, School of Medicine and Dentistry, NY 14642.
Investigative Ophthalmology & Visual Science April 1989, Vol.30, 631-637. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      R J Collier, W R Waldron, S Zigman; Temporal sequence of changes to the gray squirrel retina after near-UV exposure.. Invest. Ophthalmol. Vis. Sci. 1989;30(4):631-637.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Monocularly aphakic gray squirrels (Sciurus carolinensis) were exposed for 10 min to monochromatic near-ultraviolet radiation (lambda = 366 nm, radiant exposure = 4.3 J/cm2) to determine if their yellow pigmented lens protected retinal tissue from photochemical damage. Eyes were examined from 1 to 30 days after exposure to determine the temporal sequence of retinal damage and the extent of recovery from such exposures. Light microscopy of exposed aphakic retinas revealed irreversible lesions to the photoreceptors. Swelling of inner segments, accumulation of heavy pigment deposits in the PE, presence of macrophages in the subretinal space, and pyknosis of photoreceptor nuclei were observed in the exposed region of the aphakic eye. Eyes exposed to ultraviolet radiation with their lenses intact were devoid of significant retinal lesions. This study represents a model system for studying the potential damaging effects of near-UV radiation to the aphakic eyes of humans.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×