March 1989
Volume 30, Issue 3
Free
Articles  |   March 1989
Age differences in corneal hydration control.
Author Affiliations
  • K A Polse
    School of Optometry, University of California, Berkeley 94703.
  • R Brand
    School of Optometry, University of California, Berkeley 94703.
  • R Mandell
    School of Optometry, University of California, Berkeley 94703.
  • D Vastine
    School of Optometry, University of California, Berkeley 94703.
  • D Demartini
    School of Optometry, University of California, Berkeley 94703.
  • R Flom
    School of Optometry, University of California, Berkeley 94703.
Investigative Ophthalmology & Visual Science March 1989, Vol.30, 392-399. doi:
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    • Get Citation

      K A Polse, R Brand, R Mandell, D Vastine, D Demartini, R Flom; Age differences in corneal hydration control.. Invest. Ophthalmol. Vis. Sci. 1989;30(3):392-399.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Dynamic changes in corneal thickness were measured in eight young and eight older normal subjects (mean ages 24.4 +/- 4.3 years and 71.9 +/- 7.3 years, respectively) to provide data for quantitative assessment of corneal hydration control and thereby provide information for studying age differences in this important aspect of corneal function. For each subject, pachometry data were obtained by (A) monitoring corneal recovery following hypoxic stress, and by either (B1) measuring recovery after sleep or (B2) by measuring corneal thickness in the late afternoon. The combined data from A and B1 or A and B2 were analyzed through an exponential model to provide information on the: (1) percent recovery per hour (PRPH) following induced corneal hydration; (2) open-eye steady-state (OESS) corneal thickness; (3) residual corneal swelling just before the hypoxic stress test; (4) amount of corneal edema induced by hypoxic stress; and (5) time to reach 95% recovery back to the OESS thickness level (T95%). The results show that between the two age groups, there are substantial differences in some characteristics of corneal hydration while other aspects are similar. For example, the mean PRPH values (58.9 +/- 7.8% and 34.2 +/- 6.4%/hr) were significantly higher in the younger subjects (P = 0.0002) and the mean time for 95% recovery to OESS thickness (207 +/- 42 min and 452 +/- 117 min) was significantly lower in the younger vs. the older group (P = 0.0002).(ABSTRACT TRUNCATED AT 250 WORDS)

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