February 1989
Volume 30, Issue 2
Free
Articles  |   February 1989
Cytochalasin D disrupts outer segment disc morphogenesis in situ in rabbit retina.
Author Affiliations
  • D K Vaughan
    IES-Neuroscience Research Program, University of California, Santa Barbara.
  • S K Fisher
    IES-Neuroscience Research Program, University of California, Santa Barbara.
Investigative Ophthalmology & Visual Science February 1989, Vol.30, 339-342. doi:
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      D K Vaughan, S K Fisher; Cytochalasin D disrupts outer segment disc morphogenesis in situ in rabbit retina.. Invest. Ophthalmol. Vis. Sci. 1989;30(2):339-342.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Exposure of rabbit retina to cytochalasin D (CD) via a single intraocular injection results in basal rod outer segment (ROS) and cone OS (COS) discs with abnormally large diameters; the overgrown OS membranes extend along either the cell outer or inner segment. Twenty-four hours after the injection, basal ROS and COS discs appear to have recovered their normal diameter, indicating the reversibility of this drug's effect. These data support both the evagination hypothesis for disc morphogenesis and the hypothesis that f-actin's role at the ROS base is to regulate the initiation of membrane evagination and disc diameter.

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