March 1992
Volume 33, Issue 3
Free
Articles  |   March 1992
'On' response defect in paraneoplastic night blindness with cutaneous malignant melanoma.
Author Affiliations
  • K R Alexander
    Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine 60612.
  • G A Fishman
    Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine 60612.
  • N S Peachey
    Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine 60612.
  • A L Marchese
    Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine 60612.
  • M O Tso
    Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine 60612.
Investigative Ophthalmology & Visual Science March 1992, Vol.33, 477-483. doi:
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    • Get Citation

      K R Alexander, G A Fishman, N S Peachey, A L Marchese, M O Tso; 'On' response defect in paraneoplastic night blindness with cutaneous malignant melanoma.. Invest. Ophthalmol. Vis. Sci. 1992;33(3):477-483.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Response properties of rod and cone systems were assessed in a patient with an acquired form of night blindness associated with a metastatic cutaneous malignant melanoma. The night blindness, a sensation of shimmering lights, and selective reductions in the amplitudes of both rod and cone electroretinographic (ERG) b-waves were present before and after chemotherapy, confirming that this disorder was a paraneoplastic consequence of the melanoma rather than a response to chemotherapy. During ERG testing with flashes of extended duration, the cone b-wave abnormality was found to be a predominant loss of the cone ERG "on" response with relative preservation of the "off" response, similar to that observed in patients with congenital stationary night blindness. An impairment in signal transmission specific for retinal "on" pathways may be a primary defect in both of these forms of night blindness.

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