July 1990
Volume 31, Issue 7
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Articles  |   July 1990
Class II alloantigen induced on corneal endothelium. Role in corneal allograft rejection.
J J Donnelly; S E Orlin; Z G Wei; I M Raber; J H Rockey
Author Affiliations
  • J J Donnelly
    Department of Ophthalmology, Scheie Eye Institute, School of Medicine, University of Pennsylvania, Philadelphia.
  • S E Orlin
    Department of Ophthalmology, Scheie Eye Institute, School of Medicine, University of Pennsylvania, Philadelphia.
  • Z G Wei
    Department of Ophthalmology, Scheie Eye Institute, School of Medicine, University of Pennsylvania, Philadelphia.
  • I M Raber
    Department of Ophthalmology, Scheie Eye Institute, School of Medicine, University of Pennsylvania, Philadelphia.
  • J H Rockey
    Department of Ophthalmology, Scheie Eye Institute, School of Medicine, University of Pennsylvania, Philadelphia.
Investigative Ophthalmology & Visual Science July 1990, Vol.31, 1315-1320. doi:
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      J J Donnelly, S E Orlin, Z G Wei, I M Raber, J H Rockey; Class II alloantigen induced on corneal endothelium. Role in corneal allograft rejection.. Invest. Ophthalmol. Vis. Sci. 1990;31(7):1315-1320.

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Abstract

The expression of Class II major histocompatibility complex (MHC) antigens on corneal cells can be increased in vitro by (gamma-interferon) and in vivo in inflammatory reactions. The expression of Class II MHC by corneal endothelium of New Zealand White (NZW) rabbits during the rejection of corneal allografts was demonstrated by immunoperoxidase staining. Class II MHC expression by corneal endothelial cells may facilitate rejection of corneal allografts.

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