August 1990
Volume 31, Issue 8
Free
Articles  |   August 1990
Bacteriochlorin a, a new photosensitizer in photodynamic therapy. In vivo results.
Author Affiliations
  • J J Schuitmaker
    Department of Ophthalmology, State University of Leiden, The Netherlands.
  • J A van Best
    Department of Ophthalmology, State University of Leiden, The Netherlands.
  • J L van Delft
    Department of Ophthalmology, State University of Leiden, The Netherlands.
  • T M Dubbelman
    Department of Ophthalmology, State University of Leiden, The Netherlands.
  • J A Oosterhuis
    Department of Ophthalmology, State University of Leiden, The Netherlands.
  • D de Wolff-Rouendaal
    Department of Ophthalmology, State University of Leiden, The Netherlands.
Investigative Ophthalmology & Visual Science August 1990, Vol.31, 1444-1450. doi:https://doi.org/
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      J J Schuitmaker, J A van Best, J L van Delft, T M Dubbelman, J A Oosterhuis, D de Wolff-Rouendaal; Bacteriochlorin a, a new photosensitizer in photodynamic therapy. In vivo results.. Invest. Ophthalmol. Vis. Sci. 1990;31(8):1444-1450. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
This content is PDF only. Please click on the PDF icon to access.
Abstract

The photosensitizing properties of bacteriochlorin a (BCA), a nontoxic derivative of bacteriochlorophyll a, were investigated in vivo. BCA has an absorption band at a wavelength at which tissue penetration is optimal (760 nm), and it shows preferential tumor retention in Greene melanoma implanted in the anterior chamber of rabbit eyes. A dose of 20 mg/kg BCA was administered IV at 4-7 mm tumor diameter; 24 hr later the tumor was irradiated with near-infrared light (30 min, 760 nm, 150-280 J/cm2). On the day after the irradiation it appeared that tumor growth had stopped: fluorescein angiography showed nonperfusion of the tumor. Histopathology after enucleation showed subtotal tumor necrosis with occasionally small clusters of viable cells around a blood vessel and at the tumor periphery. Neither BCA nor light alone had any effect on the eye or melanoma.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×