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M D Larson, B R O'Donnell, B F Merrifield; Ocular hypothermia depresses the human pupillary light reflex.. Invest. Ophthalmol. Vis. Sci. 1991;32(13):3285-3287.
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Twelve human volunteers were studied to determine the effect of eye surface cooling on the parameters of the light reflex. Surface cooling resulted in a 38% decrease in the maximum constriction velocity and a 36% decrease in the maximum redilation velocity. These changes were thought to be the result of a "sluggish" response of the pupillary sphincter.
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