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D G Birch, J L Anderson; Rod visual fields in cone-rod degeneration. Comparisons to retinitis pigmentosa.. Invest. Ophthalmol. Vis. Sci. 1990;31(11):2288-2299.
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Dark-adapted visual fields to short- and long-wavelength stimuli were obtained from 20 patients with cone-rod degeneration, 20 patients with retinitis pigmentosa, and ten normal subjects. Patients were selected because they retained rod electroretinographic (ERG) function over a sufficient range for the Naka-Rushton analysis of retinal illuminance versus amplitude functions. Patients with cone-rod degeneration retained a relatively normal field topography although overall sensitivity was reduced. The mean sensitivity loss was consistent with a small elevation in ERG semisaturation constant and minimally delayed rod b-wave implicit times. Rod visual fields from patients with retinitis pigmentosa retaining rod ERG function were consistent with log sensitivity profiles reported previously for type 2 patients. Sensitivity loss was greatest in midperipheral regions, with most patients showing least loss in the far periphery. Disproportionate loss in the midperiphery is consistent with a large elevation in the ERG semisaturation constant and prolonged rod b-wave implicit times.
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