May 1992
Volume 33, Issue 6
Free
Articles  |   May 1992
Quantitative color Doppler imaging in untreated and irradiated choroidal melanoma.
Author Affiliations
  • P G Wolff-Kormann
    University Eye Hospital, Munich, FRG.
  • B A Kormann
    University Eye Hospital, Munich, FRG.
  • K G Riedel
    University Eye Hospital, Munich, FRG.
  • G C Hasenfratz
    University Eye Hospital, Munich, FRG.
  • F H Stefani
    University Eye Hospital, Munich, FRG.
  • F A Spengel
    University Eye Hospital, Munich, FRG.
  • O E Lund
    University Eye Hospital, Munich, FRG.
Investigative Ophthalmology & Visual Science May 1992, Vol.33, 1928-1933. doi:
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      P G Wolff-Kormann, B A Kormann, K G Riedel, G C Hasenfratz, F H Stefani, F A Spengel, O E Lund; Quantitative color Doppler imaging in untreated and irradiated choroidal melanoma.. Invest. Ophthalmol. Vis. Sci. 1992;33(6):1928-1933.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Histological data indicate the importance of tumor vascularization as a determinant of the biological behavior and the response to radiotherapy in choroidal melanoma. Duplex ultrasound and color Doppler imaging, the combination of B-mode ultrasound and pulse-waved Doppler analysis, were used to measure quantitatively neovascular blood flow in 31 patients with choroidal melanoma. Follow-up studies (20 patients) were performed to investigate the change of tumor blood flow in choroidal melanomas after radiotherapy. Blood flow was detected in 30 out of 31 melanomas (size 3.1-17.8 mm) within the tumor and at the tumor base with a mean peak systolic frequency of 1.0 kHz (range 0.3-2.7 kHz), a mean end diastolic frequency of 0.3 kHz (range 0.1-1.0 kHz), and a mean frequency of 0.7 kHz (range 0.2-1.3 kHz). Two and six months after 106Ru/106Rh beta-ray application, 19 patients showed a significant decrease in peak systolic frequency. This occurred with and in advance of the decrease in the tumor size. In one patient, a rising maximum systolic frequency after radiotherapy marked a recurrent tumor growth. Results indicate that the quantitative measurement of tumor blood flow by duplex ultrasound and color Doppler imaging may be a new diagnostic modality for monitoring the effectiveness of radiotherapy in choroidal melanoma.

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