April 1989
Volume 30, Issue 4
Free
Articles  |   April 1989
Further studies on the flow of aqueous humor through microporous filters.
C R Ethier; R D Kamm; M Johnson; A F Pavao; P J Anderson
Author Affiliations
  • C R Ethier
    Department of Mechanical Engineering, University of Toronto, Ontario, Canada.
  • R D Kamm
    Department of Mechanical Engineering, University of Toronto, Ontario, Canada.
  • M Johnson
    Department of Mechanical Engineering, University of Toronto, Ontario, Canada.
  • A F Pavao
    Department of Mechanical Engineering, University of Toronto, Ontario, Canada.
  • P J Anderson
    Department of Mechanical Engineering, University of Toronto, Ontario, Canada.
Investigative Ophthalmology & Visual Science April 1989, Vol.30, 739-746. doi:
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      C R Ethier, R D Kamm, M Johnson, A F Pavao, P J Anderson; Further studies on the flow of aqueous humor through microporous filters.. Invest. Ophthalmol. Vis. Sci. 1989;30(4):739-746.

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Abstract

It has recently been shown that aqueous humor is able to obstruct flow through Nuclepore polycarbonate filters having flow dimensions similar to those found in the juxtacanalicular tissue (JCT). We undertook studies designed to identify the component(s) of aqueous humor responsible for this obstruction and to determine the mechanism of blockage. We conclude that aqueous humor contains two components (one of which is specific to aqueous) which, when simultaneously present, hydrophobically bind to microporous filters and lead to filter blockage. Some implications for aqueous humor flow through the JCT are briefly discussed.

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