May 1990
Volume 31, Issue 5
Free
Articles  |   May 1990
An NMR blood test for uveal melanoma?
Author Affiliations
  • E V Smith
    Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston 02114.
  • N H Kolodny
    Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston 02114.
  • E S Gragoudas
    Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston 02114.
  • K M Egan
    Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston 02114.
  • S Finn
    Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston 02114.
  • D J D'Amico
    Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston 02114.
  • J M Seddon
    Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston 02114.
Investigative Ophthalmology & Visual Science May 1990, Vol.31, 993-997. doi:
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    • Get Citation

      E V Smith, N H Kolodny, E S Gragoudas, K M Egan, S Finn, D J D'Amico, J M Seddon; An NMR blood test for uveal melanoma?. Invest. Ophthalmol. Vis. Sci. 1990;31(5):993-997.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

In a recent article a simple nuclear magnetic resonance (NMR) blood test was suggested for the detection of the presence of cancer. The test's sensitivity to uveal melanoma of both pre- and posttreatment status has been investigated. Cases in this study were 95 patients with uveal melanoma, and controls were 70 participants in an ongoing case control study of retinal eye disease being conducted at the Massachusetts Eye and Ear Infirmary. Proton NMR evaluations at 4.7 T (200 MHz) were performed on plasma obtained from EDTA and citrated blood samples. The average line-width values were calculated from each spectrum. Statistical analysis revealed that mean proton NMR line widths were essentially equal for patients with treated (18.7 Hz) and untreated tumors (18.4 Hz) and for controls (18.5 Hz). Results based on this data set suggest that proton NMR spectroscopy has little predictive power in the detection of uveal melanoma or in the monitoring of therapy.

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