January 1992
Volume 33, Issue 1
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Articles  |   January 1992
The acute effect of topical epinephrine on macular blood flow in humans.
Author Affiliations
  • F Robinson
    Department of Ophthalmology, University of Pennsylvania School of Medicine.
  • S Chen
    Department of Ophthalmology, University of Pennsylvania School of Medicine.
  • B L Petrig
    Department of Ophthalmology, University of Pennsylvania School of Medicine.
  • J E Grunwald
    Department of Ophthalmology, University of Pennsylvania School of Medicine.
  • C E Riva
    Department of Ophthalmology, University of Pennsylvania School of Medicine.
Investigative Ophthalmology & Visual Science January 1992, Vol.33, 18-22. doi:
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    • Get Citation

      F Robinson, S Chen, B L Petrig, J E Grunwald, C E Riva; The acute effect of topical epinephrine on macular blood flow in humans.. Invest. Ophthalmol. Vis. Sci. 1992;33(1):18-22.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The acute effect of topical epinephrine HCl 2% on macular capillary blood flow was studied in 18 healthy human volunteers using the blue-field simulation technique. This technique provides a method for quantifying the velocity of leukocytes flowing in macular capillaries. Subjects adjusted the velocity of simulated leukocytes on a computer screen to match that of their own entoptically perceived leukocytes before instilling the drug and 2 hr thereafter. An artificial tear solution was instilled into the fellow eye for a control. Epinephrine instillation resulted in a 8% increase in macular leukocyte velocity and presumably blood flow (P less than 0.03, paired student t-test).

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