January 1992
Volume 33, Issue 1
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Articles  |   January 1992
Beneficial effects of a retinoic acid analog, CBS-211 A, on an experimental model of keratoconjunctivitis sicca.
Author Affiliations
  • J Y Driot
    Chauvin Laboratory Research Centre, Montpellier, France.
  • C Bonne
    Chauvin Laboratory Research Centre, Montpellier, France.
Investigative Ophthalmology & Visual Science January 1992, Vol.33, 190-195. doi:
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    • Get Citation

      J Y Driot, C Bonne; Beneficial effects of a retinoic acid analog, CBS-211 A, on an experimental model of keratoconjunctivitis sicca.. Invest. Ophthalmol. Vis. Sci. 1992;33(1):190-195.

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Abstract

We report the effects of CBS-211 A, a synthetic retinoic acid analog, on a previously described experimental model of keratoconjunctivitis sicca (KCS) in the rabbit. A 9-week topical treatment with 0.02% CBS-211 A in aqueous vehicle significantly increased the conjunctival goblet cell density (P less than 0.01, impression cytology counting), stopped the evolution of the corneo-conjunctival surface alteration (P less than 0.05, rose bengal test), and restored a basically normal mucosecretory product quality in goblet cells (lectin histochemistry) compared to vehicle treatment. The results assess the efficacy of this compound in reversing KCS pathology in a relevant model different from general vitamin A deficiency models, and strongly support the rationale for using such a well-tolerated retinoid in dry eye treatment.

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