April 1989
Volume 30, Issue 4
Free
Articles  |   April 1989
Ocular injection of retinal S antigen: suppression of autoimmune uveitis.
Author Affiliations
  • K Mizuno
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101.
  • A F Clark
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101.
  • J W Streilein
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101.
Investigative Ophthalmology & Visual Science April 1989, Vol.30, 772-774. doi:
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      K Mizuno, A F Clark, J W Streilein; Ocular injection of retinal S antigen: suppression of autoimmune uveitis.. Invest. Ophthalmol. Vis. Sci. 1989;30(4):772-774.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Uveoretinitis induced in Lewis rats by foot pad injections of retinal soluble (S) antigen is a model system used to study the immunopathogenesis of the autoimmune uveoretinitides in which delayed hypersensitivity plays a dominant role. Since down-regulation of delayed hypersensitivity can be achieved by injection of antigens into the anterior chamber of the eye, we have examined the potential of intracameral S antigen to mitigate experimental autoimmune uveitis. The results of these studies reveal that pretreatment of Lewis rats with S antigen injected into the anterior chamber markedly reduces the incidence and expression of experimental autoimmune uveitis.

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