October 1993
Volume 34, Issue 11
Articles  |   October 1993
S-cone function in patients with retinitis pigmentosa.
Author Affiliations
  • W H Swanson
    Retina Foundation of the Southwest, Dallas, TX 75231-3303.
  • D G Birch
    Retina Foundation of the Southwest, Dallas, TX 75231-3303.
  • J L Anderson
    Retina Foundation of the Southwest, Dallas, TX 75231-3303.
Investigative Ophthalmology & Visual Science October 1993, Vol.34, 3045-3055. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      W H Swanson, D G Birch, J L Anderson; S-cone function in patients with retinitis pigmentosa.. Invest. Ophthalmol. Vis. Sci. 1993;34(11):3045-3055.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements
This content is PDF only. Please click on the PDF icon to access.

PURPOSE: To determine whether short-wavelength-sensitive (S-) cones are more severely damaged in patients with retinitis pigmentosa than long-wavelength-sensitive (L-) and middle-wavelength-sensitive (M-) cones. To determine whether there are differences in the amount of S-cone damage in patients with dominant versus nondominant inheritance patterns. To accomplish these goals with methods that provide information not furnished by previous studies with two-color increment thresholds. METHODS: Acuity mediated by the S-cones was measured in 56 patients with retinitis pigmentosa, and the electroretinogram (ERG) generated by the S-cones was measured in 11 of these patients. Mixed L- and M-cone acuity, mixed L- and M-cone ERGs, and clinical full-field rod and cone ERGs were obtained for all patients. Data for both dominant and nondominant patient groups were compared with data from age-matched normal subjects. RESULTS: Only the nondominant group had reduced S-cone acuity, and 43% of patients in this group had selective reduction of S-cone acuity. In this particular sample the dominant and nondominant groups were comparable in clinical full-field ERG parameters and mixed L- and M-cone acuity, so the difference in S-cone acuities is not due to the dominant group having less advanced retinal degeneration. All 11 patients tested had reduced S-cone ERGs, 6 with significantly greater loss in the S-cone ERG than in the mixed L- and M-cone ERG. CONCLUSIONS: These data provide evidence that retinitis pigmentosa can produce greater loss of S-cones than L- and M-cones, and that this selective loss is primarily seen in patients with nondominant forms of retinitis pigmentosa.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.