October 1993
Volume 34, Issue 11
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Articles  |   October 1993
Mast cells in human optic nerve.
Author Affiliations
  • L A Levin
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston.
  • D M Albert
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston.
  • D Johnson
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston.
Investigative Ophthalmology & Visual Science October 1993, Vol.34, 3147-3153. doi:
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      L A Levin, D M Albert, D Johnson; Mast cells in human optic nerve.. Invest. Ophthalmol. Vis. Sci. 1993;34(11):3147-3153.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

PURPOSE: Mast cells are classically found in ocular tissues within the conjunctiva, choroid, and iris. The aim of this study was to examine their distribution in the optic nerve and its meninges. METHODS: Sixty-six human optic nerves were studied from normal subjects at autopsy, fetuses aborted for chromosomal abnormalities, and from enucleation specimens of patients with a variety of inflammatory, traumatic, neoplastic, and vascular disorders. Mast cells were identified using a stain for the enzyme chloroacetate esterase, and confirmed using toluidine blue, revealing metachromatic cytoplasmic granules. RESULTS: Mast cells were found scattered in the meninges of almost all optic nerves examined, frequently in perivascular locations, with densities up to 2325 mast cells/mm3 (mean 269.7 +/- 64.1 cells/mm3 in normal nerves). Mast cells were found in the optic nerve parenchyma in nerves from four eyes that had severe abnormality, often associated with neovascularization. Normal nerves, as well as nerves from fetuses aborted for congenital defects, had significantly fewer meningeal mast cells than those from eyes with inflammatory or vascular diseases. Degranulation of mast cells was observed more often in eyes with recent severe trauma. CONCLUSIONS: Based on their work and the work of others suggesting an association between mast cells and nervous system autoimmune disorders, the authors hypothesize a role for optic nerve mast cells in certain ocular inflammatory conditions.

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