March 1991
Volume 32, Issue 3
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Articles  |   March 1991
Calcitonin gene-related peptide immunoreactive nerve fibers in the rat conjunctiva.
Author Affiliations
  • J Luhtala
    Department of Anatomy, University of Helsinki, Finland.
  • A Palkama
    Department of Anatomy, University of Helsinki, Finland.
  • H Uusitalo
    Department of Anatomy, University of Helsinki, Finland.
Investigative Ophthalmology & Visual Science March 1991, Vol.32, 640-645. doi:
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      J Luhtala, A Palkama, H Uusitalo; Calcitonin gene-related peptide immunoreactive nerve fibers in the rat conjunctiva.. Invest. Ophthalmol. Vis. Sci. 1991;32(3):640-645.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Calcitonin gene-related peptide (CGRP) immunoreactive nerve fibers were studied in the rat conjunctiva by using indirect immunohistochemistry. Their origin was evaluated in a series of experiments where the animals were denervated by electrocoagulating the two first branches of the trigeminal nerve or by surgically extirpating the superior cervical ganglion. The CGRP-immunoreactive nerve fibers were seen mainly as thin varicose fibers in the epithelium and in the stroma. Many of the stromal fibers showed no apparent destination. However, CGRP-immunoreactive fibers were commonly found in association with stromal blood vessels, the smooth muscle of M├╝ller, and the meibomian glands. Approximately 40% of the ganglion cells in the trigeminal ganglion were immunoreactive to CGRP. In the superior cervical ganglion, a few CGRP-immunoreactive fibers were seen although the ganglion cells were negative. After trigeminal denervation, all the epithelial and most of the stromal CGRP-immunoreactive nerve fibers disappeared. Sympathectomy had no effect on the presence of the CGRP-immunoreactive fibers. These observations indicate that most of the CGRP-immunoreactive nerve fibers in the rat conjunctiva are sensory nerves originating in the trigeminal ganglion. A few of the demonstrated fibers are, however, resistant to the sensory denervation and may be parasympathetic in their origin.

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