January 1992
Volume 33, Issue 1
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Articles  |   January 1992
Superior cervical ganglionectomy in monkeys: surgical technique.
Author Affiliations
  • J C Robinson
    Department of Ophthalmology, University of Wisconsin School of Medicine, Madison 53792.
  • P L Kaufman
    Department of Ophthalmology, University of Wisconsin School of Medicine, Madison 53792.
Investigative Ophthalmology & Visual Science January 1992, Vol.33, 247-251. doi:
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      J C Robinson, P L Kaufman; Superior cervical ganglionectomy in monkeys: surgical technique.. Invest. Ophthalmol. Vis. Sci. 1992;33(1):247-251.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Seven cynomolgus monkeys underwent a histologically confirmed left superior cervical ganglionectomy (SCGx). Unilateral ocular sympathetic denervation persisting for at least 2 yr was confirmed by ipsilateral ptosis, miosis, supersensitivity of pupillary dilation to topical phenylephrine, and profound pupillary hyporesponsiveness to topical hydroxyamphetamine. Intraocular pressure 8-9 and 23-27 months postoperatively were identical in the denervated and contralateral control eyes. This model should facilitate studies of aqueous humor physiology and pharmacology.

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