July 1993
Volume 34, Issue 8
Free
Articles  |   July 1993
Tau-2 immunoreactivity of corpora amylacea in the human retina and optic nerve.
Author Affiliations
  • K U Loeffler
    Georgiana Dvorak Theobald Ophthalmic Pathology Laboratory, Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine 60612.
  • D P Edward
    Georgiana Dvorak Theobald Ophthalmic Pathology Laboratory, Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine 60612.
  • M O Tso
    Georgiana Dvorak Theobald Ophthalmic Pathology Laboratory, Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine 60612.
Investigative Ophthalmology & Visual Science July 1993, Vol.34, 2600-2603. doi:
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    • Get Citation

      K U Loeffler, D P Edward, M O Tso; Tau-2 immunoreactivity of corpora amylacea in the human retina and optic nerve.. Invest. Ophthalmol. Vis. Sci. 1993;34(8):2600-2603.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

PURPOSE: To characterize the constituents of corpora amylacea in the human retina and optic nerve. METHODS: Immunohistochemistry was performed on sections of retina, optic nerve, and brain tissue using antibodies against tau 1, tau-2, and amyloid precursor protein. RESULTS: Consistent anti-tau-2 immunoreactivity was noted in the corpora amylacea in the retina, optic nerve, and brain tissue, albeit with variations in pattern and intensity of staining. No immunoreactivity was observed with antibodies anti-tau 1 and anti-amyloid precursor protein. CONCLUSION: Our findings suggest the accumulation of possibly abnormal tau-2 within the corpora amylacea, which may be either astrocytic or axonal in origin.

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