September 1993
Volume 34, Issue 10
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Articles  |   September 1993
The paradoxical effect of tumor necrosis factor alpha (TNF-alpha) in endotoxin-induced uveitis.
Author Affiliations
  • L Kasner
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892.
  • C C Chan
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892.
  • S M Whitcup
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892.
  • I Gery
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892.
Investigative Ophthalmology & Visual Science September 1993, Vol.34, 2911-2917. doi:
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    • Get Citation

      L Kasner, C C Chan, S M Whitcup, I Gery; The paradoxical effect of tumor necrosis factor alpha (TNF-alpha) in endotoxin-induced uveitis.. Invest. Ophthalmol. Vis. Sci. 1993;34(10):2911-2917.

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Abstract

PURPOSE: To investigate the role of TNF-alpha in endotoxin-induced uveitis (EIU) in mice. METHODS: To neutralize TNF-alpha activity, mice were pretreated with either repeated injections of this cytokine or a single injection of antibody against it. The mice were then injected intraperitoneally with 500 micrograms endotoxin, to induce lethal septic shock, or into the footpad with 200 micrograms to induce EIU. RESULTS: Although both pretreatments conferred protection against the systemic toxic effects of LPS, TNF-resistant mice and mice treated with anti-TNF-alpha antibody demonstrated an exacerbation of EIU when compared to control animals. CONCLUSIONS: Unlike its apparent participation in the systemic effect of endotoxin, TNF-alpha is not directly involved in the pathogenesis of EIU and may even protect against the inflammatory processes of this disease.

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