April 1992
Volume 33, Issue 5
Free
Articles  |   April 1992
Abnormal dark adaptation and rhodopsin kinetics in Sorsby's fundus dystrophy.
Author Affiliations
  • R L Steinmetz
    Department of Clinical Ophthalmology, Institute of Ophthalmology, London, England.
  • P C Polkinghorne
    Department of Clinical Ophthalmology, Institute of Ophthalmology, London, England.
  • F W Fitzke
    Department of Clinical Ophthalmology, Institute of Ophthalmology, London, England.
  • C M Kemp
    Department of Clinical Ophthalmology, Institute of Ophthalmology, London, England.
  • A C Bird
    Department of Clinical Ophthalmology, Institute of Ophthalmology, London, England.
Investigative Ophthalmology & Visual Science April 1992, Vol.33, 1633-1636. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      R L Steinmetz, P C Polkinghorne, F W Fitzke, C M Kemp, A C Bird; Abnormal dark adaptation and rhodopsin kinetics in Sorsby's fundus dystrophy.. Invest. Ophthalmol. Vis. Sci. 1992;33(5):1633-1636.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Scotopic visual thresholds and time courses for dark adaptation were determined in eight patients with Sorsby's fundus dystrophy. Rhodopsin regeneration also was recorded in two. All patients had poor night vision and a visible yellow deposit at the level of Bruch's membrane that was confluent in the posterior pole. In retinal regions with the yellow deposit, scotopic thresholds were elevated, the rod-cone break was delayed or indistinct, the time courses for the rod portion of the dark adaptation curve was prolonged, and rhodopsin regeneration was slow in the one patient in whom measurements were made. In regions of ophthalmoscopically normal retina, dark adaptation was affected minimally, and in one patient, rhodopsin was regenerated at a normal rate. It was hypothesized that the abnormal dark adaptation and rhodopsin kinetics might be caused by reduced metabolic exchange across a thickened Bruch's membrane.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×