August 1993
Volume 34, Issue 9
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Articles  |   August 1993
Sites of cone system sensitivity loss in retinitis pigmentosa.
Author Affiliations
  • W H Seiple
    Department of Ophthalmology, New York University Medical Center, NY 10016.
  • K Holopigian
    Department of Ophthalmology, New York University Medical Center, NY 10016.
  • V C Greenstein
    Department of Ophthalmology, New York University Medical Center, NY 10016.
  • D C Hood
    Department of Ophthalmology, New York University Medical Center, NY 10016.
Investigative Ophthalmology & Visual Science August 1993, Vol.34, 2638-2645. doi:
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    • Get Citation

      W H Seiple, K Holopigian, V C Greenstein, D C Hood; Sites of cone system sensitivity loss in retinitis pigmentosa.. Invest. Ophthalmol. Vis. Sci. 1993;34(9):2638-2645.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

PURPOSE: To examine the sites of cone sensitivity loss in patients with retinitis pigmentosa by comparing focal electroretinographic and psychophysical modulation thresholds. METHODS: Both psychophysical and electrophysiologic increment threshold curves were obtained in retinitis pigmentosa patients and a group of age-matched, normally-sighted adults. RESULTS: The majority of the retinitis pigmentosa data could be accounted for by a vertical displacement of the normal curve. The retinitis pigmentosa patients showed similar patterns of cone sensitivity losses using both techniques. CONCLUSIONS: The combined electrophysiologic and psychophysical results provide support for an outer retina locus for these cone sensitivity losses. The data suggest that these deficits may be caused by a spatially independent loss of cone photoreceptors with normal adaptation properties in the remaining photoreceptors.

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