November 1993
Volume 34, Issue 12
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Articles  |   November 1993
Subretinal space and vitreous cavity as immunologically privileged sites for retinal allografts.
Author Affiliations
  • L Q Jiang
    Department of Microbiology and Immunology, University of Miami School of Medicine, Florida.
  • M Jorquera
    Department of Microbiology and Immunology, University of Miami School of Medicine, Florida.
  • J W Streilein
    Department of Microbiology and Immunology, University of Miami School of Medicine, Florida.
Investigative Ophthalmology & Visual Science November 1993, Vol.34, 3347-3354. doi:
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      L Q Jiang, M Jorquera, J W Streilein; Subretinal space and vitreous cavity as immunologically privileged sites for retinal allografts.. Invest. Ophthalmol. Vis. Sci. 1993;34(12):3347-3354.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

PURPOSE: Because immune rejection is likely to be a major barrier to successful retinal transplantation, it is important to determine whether immune privilege for allogeneic retinal grafts is a feature of the subretinal space and vitreous cavity. METHODS: Newborn neural retinas of C57BL/6 mice were implanted into the subretinal space, vitreous cavity, or subconjunctival space of eyes of adult BALB/c (disparate from C57BL/6 at major and minor histocompatibility loci). At postimplantation day 12, the recipients were evaluated for donor-specific delayed hypersensitivity and examined clinically and histologically for evidence of rejection. RESULTS: Newborn neural retinal allografts in the subconjunctival space were destroyed by postimplantation day 12 and these recipients displayed intense donor-specific delayed hypersensitivity. By contrast, grafts in the subretinal space and vitreous cavity at postimplantation day 12 were found to be well differentiated and with no evidence of inflammation; these recipients failed to display donor-specific delayed hypersensitivity. Moreover, their spleens contained regulatory T cells that suppressed donor-specific delayed hypersensitivity in naive syngeneic recipients. CONCLUSIONS: Allogeneic newborn neural retinal grafts implanted in the subretinal space and vitreous cavity experience immune privilege and induce deviant immune responses resembling anterior chamber associated immune deviation.

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