March 1994
Volume 35, Issue 3
Free
Articles  |   March 1994
Complement system and host defense against staphylococcal endophthalmitis.
M J Giese; B J Mondino; B J Glasgow; H L Sumner; S A Adamu; H P Halabi; H J Chou
Author Affiliations
  • M J Giese
    Jules Stein Eye Institute, University of California at Los Angeles 90024-1771.
  • B J Mondino
    Jules Stein Eye Institute, University of California at Los Angeles 90024-1771.
  • B J Glasgow
    Jules Stein Eye Institute, University of California at Los Angeles 90024-1771.
  • H L Sumner
    Jules Stein Eye Institute, University of California at Los Angeles 90024-1771.
  • S A Adamu
    Jules Stein Eye Institute, University of California at Los Angeles 90024-1771.
  • H P Halabi
    Jules Stein Eye Institute, University of California at Los Angeles 90024-1771.
  • H J Chou
    Jules Stein Eye Institute, University of California at Los Angeles 90024-1771.
Investigative Ophthalmology & Visual Science March 1994, Vol.35, 1026-1032. doi:
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      M J Giese, B J Mondino, B J Glasgow, H L Sumner, S A Adamu, H P Halabi, H J Chou; Complement system and host defense against staphylococcal endophthalmitis.. Invest. Ophthalmol. Vis. Sci. 1994;35(3):1026-1032.

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Abstract

PURPOSE: The authors studied the role of the complement system in host defense against Staphylococcus epidermidis and S. aureus endophthalmitis. METHODS: Guinea pigs in the S. epidermidis model received an intravitreal injection of 7000 viable organisms, and guinea pigs in the S. aureus model received 50 viable organisms. The experimental animals in each model were decomplemented with intraperitoneal (IP) injections of cobra venom factor, whereas the control animals received IP injections of normal saline. Mean log bacterial counts in the vitreous and mean serum complement titers were compared in the experimental and control animals in each model on days 1, 2, 3, and 7. RESULTS: In the S. epidermidis model, mean log bacterial counts in the vitreous were significantly higher in the experimental group than the control group on days 1 and 2 (P < 0.01) and on day 3 (P < 0.05). Mean serum complement titers were significantly lower in the experimental group at all days (P < 0.01). In the S. aureus model, mean log bacterial counts in the vitreous were significantly higher in the experimental group than the control group on day 2 (P < 0.05) and day 3 (P < 0.01). Mean serum complement titers were significantly lower in the experimental group on days 1, 2, and 3 (P < 0.01), but not on day 7. CONCLUSION: These results suggest that decomplemented guinea pigs show impaired host defense to S. epidermidis and S. aureus endophthalmitis and that this defense is restored as complement levels approach normal.

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