April 1992
Volume 33, Issue 5
Free
Articles  |   April 1992
Antibodies to a 15 kD nuclear antigen in patients with juvenile chronic arthritis and uveitis.
Author Affiliations
  • G H Neuteboom
    Department of Ophthalmo-Immunology, Netherlands Ophthalmic Research Institute, Amsterdam.
  • R Hertzberger-ten Cate
    Department of Ophthalmo-Immunology, Netherlands Ophthalmic Research Institute, Amsterdam.
  • J de Jong
    Department of Ophthalmo-Immunology, Netherlands Ophthalmic Research Institute, Amsterdam.
  • H G van den Brink
    Department of Ophthalmo-Immunology, Netherlands Ophthalmic Research Institute, Amsterdam.
  • T E Feltkamp
    Department of Ophthalmo-Immunology, Netherlands Ophthalmic Research Institute, Amsterdam.
Investigative Ophthalmology & Visual Science April 1992, Vol.33, 1657-1660. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      G H Neuteboom, R Hertzberger-ten Cate, J de Jong, H G van den Brink, T E Feltkamp; Antibodies to a 15 kD nuclear antigen in patients with juvenile chronic arthritis and uveitis.. Invest. Ophthalmol. Vis. Sci. 1992;33(5):1657-1660.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Young girls with a pauciarticular onset of juvenile chronic arthritis and circulating antinuclear antibodies are at risk for chronic uveitis. The actual nuclear antigen for these antinuclear antibodies has not been defined. Conventional laboratory techniques, such as counter immunoelectrophoresis, have shown that antibodies to well defined "extractable nuclear antigens" (eg, RNP, Sm, SS-A, and SS-B) are not present in patients with juvenile chronic arthritis. Therefore, other, previously unknown nuclear antigens may be involved. Sera of 64 patients with juvenile chronic arthritis, including 22 patients with chronic anterior uveitis, were studied using the immunoblotting technique to characterize the nuclear antigens. Antinuclear antibodies were present in 12 (55%) of the 22 patients with uveitis, and only in six (14%) of the 42 patients without chronic anterior uveitis. With the immunoblotting technique, antibodies to a 15 kD nuclear antigen were found in 10 (45%) of the 22 patients with chronic anterior uveitis, whereas only two (5%) of the 42 patients without chronic anterior uveitis showed these antibodies (P less than 0.001). Only clearly visible and reproducible lines in the immunoblotting patterns were studied. This may provide a diagnostic tool for the early detection of uveitis and means for further pathogenetic studies.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×