August 1993
Volume 34, Issue 9
Free
Articles  |   August 1993
Combination drug testing of Mycobacterium chelonae.
Author Affiliations
  • A Y Matoba
    Houston Veterans Affair Medical Center, Baylor College of Medicine, Houston, Texas.
  • B L Lee
    Houston Veterans Affair Medical Center, Baylor College of Medicine, Houston, Texas.
  • N M Robinson
    Houston Veterans Affair Medical Center, Baylor College of Medicine, Houston, Texas.
  • R Penland
    Houston Veterans Affair Medical Center, Baylor College of Medicine, Houston, Texas.
  • M S Osato
    Houston Veterans Affair Medical Center, Baylor College of Medicine, Houston, Texas.
Investigative Ophthalmology & Visual Science August 1993, Vol.34, 2786-2789. doi:
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    • Get Citation

      A Y Matoba, B L Lee, N M Robinson, R Penland, M S Osato; Combination drug testing of Mycobacterium chelonae.. Invest. Ophthalmol. Vis. Sci. 1993;34(9):2786-2789.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

PURPOSE: Medical therapy of Mycobacterium chelonae keratitis is difficult because there are so few effective antimicrobial agents and single agent therapy frequently fails clinically. To identify more effective medical treatment regimens, the in vitro antimicrobial efficacy of amikacin, the most frequently used single agent, was investigated in combination with four antibiotics previously reported to have activity against M. chelonae: erythromycin, imipenem, ciprofloxacin, and vancomycin. METHODS: The drug combinations were tested by the checkerboard method against seven corneal isolates of M. chelonae. RESULTS: The combination of amikacin with erythromycin or vancomycin consistently led to synergistic or additive effect, however the minimum inhibitory concentrations for vancomycin were very high. The combination of amikacin with imipenem or ciprofloxacin led to results ranging from antagonism to additive effects. CONCLUSIONS: Of the antibiotics tested, erythromycin showed the most activity against M. chelonae in combination with amikacin. In vitro combination drug testing of M. chelonae by the checkerboard method should be further evaluated for clinical relevance in microbial keratitis.

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