November 1990
Volume 31, Issue 11
Articles  |   November 1990
Angiotensin-II contracts isolated human posterior ciliary arteries.
Author Affiliations
  • N C Nyborg
    Department of Pharmacology, Aarhus University, Denmark.
  • P J Nielsen
    Department of Pharmacology, Aarhus University, Denmark.
Investigative Ophthalmology & Visual Science November 1990, Vol.31, 2471-2473. doi:
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      N C Nyborg, P J Nielsen; Angiotensin-II contracts isolated human posterior ciliary arteries.. Invest. Ophthalmol. Vis. Sci. 1990;31(11):2471-2473.

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      © ARVO (1962-2015); The Authors (2016-present)

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The effect of angiotensin-II (A-II) was studied on ring segments of the terminal extraocular branches of the posterior ciliary artery isolated from human enucleated eyes. It induced a potent concentration-dependent contraction on top of the spontaneous myogenic tone of all arteries studied from five patients with the concentration required to give half-maximal response equal to 51 nM. The spontaneous tone and maximal increase in vessel wall tension induced by A-II was equal to 51% of Emax. The relative response and sensitivity to A-II was unchanged in three endothelial denuded vessels, but the spontaneous tone increased. The arteries became completely insensitive to A-II after one exposure. These results show an immediate direct contractile effect of A-II on human posterior ciliary arteries, but the development of pronounced tachyphylaxis indicates that A-II is probably not an important factor in reducing blood flow to the optic nerve head.


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