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J Semel, B Bowe, A Guo, L Lee, L Rife, D Polikoff, P Summanen, G Pararajasegaram, S M Finegold, N Rao; Propionibacterium acnes-enhanced lens-induced granulomatous uveitis in the rat.. Invest. Ophthalmol. Vis. Sci. 1992;33(5):1766-1770.
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Propionibacterium acnes (Corynebacterium parvum) is being implicated more frequently as a cause of intraocular inflammation following cataract surgery. In addition to its role as an infectious agent, P. acnes also may possess adjuvant-like or adjuvant-enhancing properties. The presence of this organism in an eye with residual lens material after extracapsular cataract surgery could augment inflammation resulting from a phacoantigenic (phacoanaphylactic) response. We have modified an established rat model of lens-induced granulomatous uveitis (LIGU) to examine the adjuvant properties of P. acnes. Our results suggest that P. acnes effectively potentiates LIGU.
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