April 1992
Volume 33, Issue 5
Free
Articles  |   April 1992
Propionibacterium acnes-enhanced lens-induced granulomatous uveitis in the rat.
Author Affiliations
  • J Semel
    Doheny Eye Institute, Los Angeles, CA.
  • B Bowe
    Doheny Eye Institute, Los Angeles, CA.
  • A Guo
    Doheny Eye Institute, Los Angeles, CA.
  • L Lee
    Doheny Eye Institute, Los Angeles, CA.
  • L Rife
    Doheny Eye Institute, Los Angeles, CA.
  • D Polikoff
    Doheny Eye Institute, Los Angeles, CA.
  • P Summanen
    Doheny Eye Institute, Los Angeles, CA.
  • G Pararajasegaram
    Doheny Eye Institute, Los Angeles, CA.
  • S M Finegold
    Doheny Eye Institute, Los Angeles, CA.
  • N Rao
    Doheny Eye Institute, Los Angeles, CA.
Investigative Ophthalmology & Visual Science April 1992, Vol.33, 1766-1770. doi:
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    • Get Citation

      J Semel, B Bowe, A Guo, L Lee, L Rife, D Polikoff, P Summanen, G Pararajasegaram, S M Finegold, N Rao; Propionibacterium acnes-enhanced lens-induced granulomatous uveitis in the rat.. Invest. Ophthalmol. Vis. Sci. 1992;33(5):1766-1770.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Propionibacterium acnes (Corynebacterium parvum) is being implicated more frequently as a cause of intraocular inflammation following cataract surgery. In addition to its role as an infectious agent, P. acnes also may possess adjuvant-like or adjuvant-enhancing properties. The presence of this organism in an eye with residual lens material after extracapsular cataract surgery could augment inflammation resulting from a phacoantigenic (phacoanaphylactic) response. We have modified an established rat model of lens-induced granulomatous uveitis (LIGU) to examine the adjuvant properties of P. acnes. Our results suggest that P. acnes effectively potentiates LIGU.

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