May 1992
Volume 33, Issue 6
Free
Articles  |   May 1992
Ultrastructural immunocytochemical localization of chondroitin sulfate proteoglycan in Bruch's membrane of the rat.
Author Affiliations
  • W L Lin
    Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Michigan.
  • E Essner
    Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Michigan.
  • K J McCarthy
    Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Michigan.
  • J R Couchman
    Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Michigan.
Investigative Ophthalmology & Visual Science May 1992, Vol.33, 2072-2075. doi:
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    • Get Citation

      W L Lin, E Essner, K J McCarthy, J R Couchman; Ultrastructural immunocytochemical localization of chondroitin sulfate proteoglycan in Bruch's membrane of the rat.. Invest. Ophthalmol. Vis. Sci. 1992;33(6):2072-2075.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Two monoclonal antibodies (Mab 4D5 and 2D6) raised against the core protein of a basement membrane chondroitin sulfate proteoglycan from Reichert's membrane of the rat, were used for ultrastructural immunoperoxidase localization of this protein in Bruch's membrane of the rat. Immunoreactivity for both antibodies was found in the basal lamina (basement membrane) of the choriocapillary endothelium and retinal pigment epithelium, in collagen fibers in the collagenous zones, and surrounding the elastic layer.

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