November 1998
Volume 39, Issue 12
Articles  |   November 1998
A biometric study of the eye, orbit, and face in 205 normal human fetuses.
Author Affiliations
  • D Denis
    Hôpital La Timone, Marseille, France.
  • O Burguière
    Hôpital La Timone, Marseille, France.
  • C Burillon
    Hôpital La Timone, Marseille, France.
Investigative Ophthalmology & Visual Science November 1998, Vol.39, 2232-2238. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      D Denis, O Burguière, C Burillon; A biometric study of the eye, orbit, and face in 205 normal human fetuses.. Invest. Ophthalmol. Vis. Sci. 1998;39(12):2232-2238.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements
This content is PDF only. Please click on the PDF icon to access.

PURPOSE: To develop models for assessing the differential growth of the fetal face along its horizontal and vertical axes, as well as of the orbit and the eye. METHODS: Normal human fetuses (n = 205), whose gestational ages ranged from 15.5 to 41 weeks of amenorrhea, were examined. Orbitofacial parameters were as follows: outer canthal distance, inner canthal distance, palpebral fissure length, and oropalpebral distance. Ocular parameters were corneal diameter and axial length. Correlations were tested among all parameters. Linear and polynomial regression analyses of gestational age and the orbitofacial and ocular parameters were used to develop models of growth. Differential patterns of growth in the face were investigated. RESULTS: The best correlation was found between palpebral fissure length and oropalpebral distance. The increase of each of the parameters studied could be accurately described by a linear model. Sex had no detectable effect on these parameters. Compared with the skull, the face had a more rapid growth along the vertical axis. The palpebral fissure developed more rapidly than the eye. CONCLUSIONS: The parameters that were studied in the fetal face, orbit, and eye follow a roughly linear growth curve.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.