December 1998
Volume 39, Issue 13
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Articles  |   December 1998
Baseline findings in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study.
Author Affiliations
  • K Zadnik
    College of Optometry, The Ohio State University, Columbus 43210-1240, USA.
  • J T Barr
    College of Optometry, The Ohio State University, Columbus 43210-1240, USA.
  • T B Edrington
    College of Optometry, The Ohio State University, Columbus 43210-1240, USA.
  • D F Everett
    College of Optometry, The Ohio State University, Columbus 43210-1240, USA.
  • M Jameson
    College of Optometry, The Ohio State University, Columbus 43210-1240, USA.
  • T T McMahon
    College of Optometry, The Ohio State University, Columbus 43210-1240, USA.
  • J A Shin
    College of Optometry, The Ohio State University, Columbus 43210-1240, USA.
  • J L Sterling
    College of Optometry, The Ohio State University, Columbus 43210-1240, USA.
  • H Wagner
    College of Optometry, The Ohio State University, Columbus 43210-1240, USA.
  • M O Gordon
    College of Optometry, The Ohio State University, Columbus 43210-1240, USA.
Investigative Ophthalmology & Visual Science December 1998, Vol.39, 2537-2546. doi:
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    • Get Citation

      K Zadnik, J T Barr, T B Edrington, D F Everett, M Jameson, T T McMahon, J A Shin, J L Sterling, H Wagner, M O Gordon; Baseline findings in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study.. Invest. Ophthalmol. Vis. Sci. 1998;39(13):2537-2546.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

PURPOSE: To describe the baseline findings in patients enrolled in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study. METHODS: This is a longitudinal observational study of 1209 patients with keratoconus enrolled at 16 clinical centers. Its main outcome measures are corneal scarring, visual acuity, keratometry, and quality of life. RESULTS: The CLEK Study patients had a mean age of 39.29+/-10.90 years with moderate to severe disease, assessed by a keratometric-based criterion (95.4% of patients had steep keratometric readings of at least 45 D) and relatively good visual acuity (77.9% had best corrected visual acuity of at least 20/40 in both eyes). Sixty-five percent of the patients wore rigid gas-permeable contact lens, and most of those (73%) reported that their lenses were comfortable. Only 13.5% of patients reported a family history of keratoconus. None reported serious systemic diseases that had been previously reported to be associated with keratoconus. Many (53%) reported a history of atopy. Fifty-three percent had corneal scarring in one or both eyes. CONCLUSIONS: Baseline findings suggest that keratoconus is not associated with increased risk of connective tissue disease and that most patients in the CLEK Study sample represent mild to moderate keratoconus. Additional follow-up of at least 3 years will provide new information about the progression of keratoconus, identify factors associated with progression, and assess its impact on quality of life.

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