September 1998
Volume 39, Issue 10
Free
Articles  |   September 1998
Müller cell-specific autoantibodies in a patient with progressive loss of vision.
Author Affiliations
  • R Peek
    Netherlands Ophthalmic Research Institute, Amsterdam.
  • F Verbraak
    Netherlands Ophthalmic Research Institute, Amsterdam.
  • H M Coevoet
    Netherlands Ophthalmic Research Institute, Amsterdam.
  • A Kijlstra
    Netherlands Ophthalmic Research Institute, Amsterdam.
Investigative Ophthalmology & Visual Science September 1998, Vol.39, 1976-1979. doi:https://doi.org/
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      R Peek, F Verbraak, H M Coevoet, A Kijlstra; Müller cell-specific autoantibodies in a patient with progressive loss of vision.. Invest. Ophthalmol. Vis. Sci. 1998;39(10):1976-1979. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

PURPOSE: To study the specificity of circulating retinal autoantibodies in a patient with progressive loss of vision resembling cancer-associated retinopathy in the absence of systemic malignancy. METHODS: Patient's serum was tested for the presence of antiretinal antibodies by Western blot analysis, and immunohistochemical analysis was performed on cryosections of rat retina and on cultured rat retinal Müller cells. RESULTS: Western blot analysis revealed that the serum contained a high titer of autoantibodies against a 35-kDa retinal antigen. A protein of similar molecular weight and antigenicity has been found to be present in protein extracts of bovine, rat, and fish retina. Immunohistochemical analysis suggested that the autoantibodies did not localize to retinal neural cells, as reported for several other putative autoimmune retinal disorders, but rather to the retinal Müller cells. This cell type-specificity could be confirmed using purified cultured retinal Müller cells. CONCLUSIONS: These results suggest that an autoimmune response directed against the retinal Müller cells, in the absence of overt systemic malignancy, may lead to a slow-developing visual deterioration.

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