October 1998
Volume 39, Issue 11
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Articles  |   October 1998
Effect of glutamate analogues and inhibitory neurotransmitters on the electroretinograms elicited by random sequence stimuli in rabbits.
Author Affiliations
  • M Horiguchi
    Department of Ophthalmology, Nagoya University School of Medicine, Japan.
  • S Suzuki
    Department of Ophthalmology, Nagoya University School of Medicine, Japan.
  • M Kondo
    Department of Ophthalmology, Nagoya University School of Medicine, Japan.
  • A Tanikawa
    Department of Ophthalmology, Nagoya University School of Medicine, Japan.
  • Y Miyake
    Department of Ophthalmology, Nagoya University School of Medicine, Japan.
Investigative Ophthalmology & Visual Science October 1998, Vol.39, 2171-2176. doi:
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      M Horiguchi, S Suzuki, M Kondo, A Tanikawa, Y Miyake; Effect of glutamate analogues and inhibitory neurotransmitters on the electroretinograms elicited by random sequence stimuli in rabbits.. Invest. Ophthalmol. Vis. Sci. 1998;39(11):2171-2176.

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Abstract

OBJECTIVE: To study the origin of the different components of the electroretinogram (ERG) elicited by a random binary m-sequence stimulus. METHODS: Electroretinograms were recorded from pigmented rabbits before and after the injection of glutamate analogues (2-amino-4-phosphono-butyric acid [APB; DL form] and cis-2,3-piperidine-dicarboxylic acid [PDA]) and inhibitory neurotransmitters (glycine and gamma-aminobutyric acid [GABA]) to abolish the contribution of different cell types to the ERG. Two types of stimuli were used: conventional full-field stimulation with short- and long-duration flashes and a random binary m-sequence of flashes designed to mimic the pseudorandom binary m-sequence stimulation used in the multifocal ERG technique. RESULTS: The effects of APB and PDA on the first-order kernel of the random ERGs were similar to those on the photopic short-flash ERG. Glycine and GABA minimized the oscillatory potentials (OPs) of the photopic ERGs, and also reduced the amplitude of the positive wave of the first-order kernel slightly but caused a large reduction in the amplitude of the second-order kernel. CONCLUSIONS: The data suggest that the ON and OFF bipolar cells contribute significantly to the photopic short-flash ERG, as previously shown, and to the first-order kernel of the responses elicited by the pseudorandom binary sequence stimuli. The second-order kernel and the OPs receive a strong contribution from the cells of the inner retinal layers.

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