April 1999
Volume 40, Issue 5
Free
Articles  |   April 1999
Effect of staurosporine on outflow facility in monkeys.
Author Affiliations
  • B Tian
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison 53792-3220, USA.
  • B T Gabelt
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison 53792-3220, USA.
  • P L Kaufman
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison 53792-3220, USA.
Investigative Ophthalmology & Visual Science April 1999, Vol.40, 1009-1011. doi:
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    • Get Citation

      B Tian, B T Gabelt, P L Kaufman; Effect of staurosporine on outflow facility in monkeys.. Invest. Ophthalmol. Vis. Sci. 1999;40(5):1009-1011.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

PURPOSE: To determine the effect of the serine-threonine kinase inhibitor staurosporine on outflow facility in living monkeys. METHODS: Total outflow facility was determined by two-level constant pressure perfusion of the anterior chamber bilaterally before and after intracameral infusion of staurosporine or vehicle in opposite eyes. RESULTS: Intracameral staurosporine dose-dependently doubled outflow facility, with 0.1 microM, 1 microM, and 10 microM being subthreshold, effective, and maximal doses, respectively. At 50 microM, intracameral staurosporine was less effective than 10 microM on facility and induced corneal toxicity. CONCLUSIONS: The broad-spectrum protein kinase inhibitor staurosporine increases outflow facility in living monkeys, perhaps by affecting the trabecular meshwork cytoskeleton.

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