January 1999
Volume 40, Issue 1
Free
Articles  |   January 1999
H-7 increases trabecular facility and facility after ciliary muscle disinsertion in monkeys.
Author Affiliations
  • B Tian
    Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, 53792-3220, USA.
  • B T Gabelt
    Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, 53792-3220, USA.
  • J A Peterson
    Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, 53792-3220, USA.
  • J A Kiland
    Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, 53792-3220, USA.
  • P L Kaufman
    Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, 53792-3220, USA.
Investigative Ophthalmology & Visual Science January 1999, Vol.40, 239-242. doi:
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    • Get Citation

      B Tian, B T Gabelt, J A Peterson, J A Kiland, P L Kaufman; H-7 increases trabecular facility and facility after ciliary muscle disinsertion in monkeys.. Invest. Ophthalmol. Vis. Sci. 1999;40(1):239-242.

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Abstract

PURPOSE: To determine the effects of the serine-threonine kinase inhibitor H-7 on total outflow facility in iridectomized + ciliary muscle (CM)- disinserted, and on trabecular facility in normal, monkey eyes. METHODS: Total outflow facility was determined by two-level constant pressure perfusion of the anterior chamber. Trabecular outflow facility was determined from accumulation in blood of intracamerally infused radioiodinated albumin at two intraocular pressure levels. RESULTS: Three-hundred micromoles of intracameral H-7 doubled facility in iridectomized + CM- disinserted monkey eyes and contralateral iridectomized-only eyes. Four 5-microl drops of 400 mM H-7 applied topically followed 2 hours later by anterior chamber exchange for 10 minutes and intracameral infusion for 90 minutes with 100 microM H-7 increased trabecular and total outflow facility by 135%+/-29% and 105%+/-35% (n 5, P < 0.01, P < 0.05), respectively, compared with contralateral vehicle-treated eyes. CONCLUSIONS: H-7 increases trabecular outflow facility in monkeys by a mechanism independent of the CM, presumably acting directly on the trabecular meshwork.

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