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Martin J. Lizak, Manuel B. Datiles, Anthony H. Aletras, Peter F. Kador, Robert S. Balaban; MRI of the Human Eye Using Magnetization Transfer Contrast Enhancement. Invest. Ophthalmol. Vis. Sci. 2000;41(12):3878-3881.
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purpose. To determine the feasibility of using magnetization transfer
contrast–enhanced magnetic resonance imaging (MRI) to track
cataractous lens changes.
methods. A fast spin–echo sequence was modified to include a magnetization
transfer contrast (MTC) preparation pulse train. This consisted of
twenty 8.5-msec sinc pulses, 1200 Hz upfield from the water
resonance and 1.2-Hz power. The MTC preparation pulse was followed by
acquisition through fast spin–echo imaging. The imaging parameters
were number of excitations (NEX) = 1, echo time (TE) = 14 msec, recovery time (TR) = 2 sec, echo train length of eight
echos, and a matrix size of 256 × 160. To reduce motion
artifacts, the volunteers were asked to fixate on a blinking LED.
Normal and MTC-enhanced images were acquired from normal volunteers and
volunteers with nuclear or cortical cataracts.
results. The eye was adequately imaged, with few motion artifacts appearing. The
lens was well resolved, despite the short T2. The cornea
and ciliary body were also clearly visible. In the lens, resolution of
the epithelium and cortex were enhanced with MTC. In addition,
contrast-to-noise ratios were measured for each image. Examination of
the contrast-to-noise ratio confirmed that MTC increased the contrast
between the nucleus and cortex. Unenhanced MRIs showed significant
differences between the cortex of normal volunteers and volunteers with
cataracts. MTC-enhanced images improved the sensitivity to changes in
conclusions. In this preliminary study, we were able to use MTC-enhanced MRI to
obtain high-contrast images of the human lens. Regular and enhanced
MRIs detected statistically significant differences between normal and
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